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Landmark 100/100

Vegetarian diets and cancer risk — pooled analysis of 1.8 million adults across three continents

In plain English

The largest study ever of vegetarian diets and cancer, pooling nine prospective cohorts across the UK, US, Taiwan and India — 1.8 million people including over 60,000 vegetarians and nearly 9,000 vegans — followed for a median 16 years. Lower-meat diets were associated with reduced risk of five cancers, with vegetarians and pescatarians showing lower rates of colorectal, breast, prostate, stomach and other cancers. Honestly, the picture was not uniform: vegans showed a slightly higher colorectal cancer risk, a finding the authors flag for further scrutiny.

Why it matters

Across 1.8M adults on three continents, vegetarian and low-meat diets were linked to lower risk of five cancers.

Informs: Cancer·Plant-Based Score

Provenance

Design
Meta-analysis
Sample size (n)
1,817,477
Follow-up
16 years
Peer-reviewed
Yes
Replications
3
Funding
Public / academic
Funders
Cancer Research UK, World Cancer Research Fund, Wellcome Trust
Institutions
University of Oxford (Cancer Epidemiology Unit), Tzu Chi University Taiwan

decades.plus score

A transparent 0–100 weighted sum across six components. Higher scores reflect bigger, cleaner, more replicated work.

Landmark 100/100
  • Study design 25/25
  • Sample size 20/20
  • Funding independence 20/20
  • Journal + peer review 15/15
  • Institution tier 10/10
  • Replication 10/10

Caveats

Observational; diet was self-reported and people who avoid meat differ in smoking, weight and wealth despite adjustment. The unexpected higher colorectal risk among vegans may reflect chance, reverse causation, or differences in processed plant-food intake — it needs replication.