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Landmark 95/100

EPIC — Meat, fish, and colorectal cancer risk

In plain English

Over half a million Europeans in the EPIC cohort were followed for their meat intake and incidence of colorectal cancer. Each additional 50 g/day of processed meat was associated with an 18% higher risk of colorectal cancer — the central data point underpinning the WHO's 2015 carcinogen classification.

Why it matters

Each 50 g/day processed meat → 18% higher colorectal cancer risk.

Informs: Cancer

Provenance

Design
Prospective cohort
Sample size (n)
521,000
Follow-up
5 years
Peer-reviewed
Yes
Replications
4
Funding
Public / academic
Funders
European Commission, national research councils
Institutions
International Agency for Research on Cancer (IARC), European EPIC consortium

decades.plus score

A transparent 0–100 weighted sum across six components. Higher scores reflect bigger, cleaner, more replicated work.

Landmark 95/100
  • Study design 20/25
  • Sample size 20/20
  • Funding independence 20/20
  • Journal + peer review 15/15
  • Institution tier 10/10
  • Replication 10/10

Caveats

Observational; relative risk is on a small absolute baseline (~5% lifetime risk in many Western countries). Adjusts for major confounders but residual confounding is always possible.