Landmark 87/100
Lyon Diet Heart Study
In plain English
After a first heart attack, 605 patients were randomised to either a Mediterranean-pattern diet or the standard American Heart Association control diet. Within four years the Mediterranean group had 72% fewer cardiac events. It was one of the first hard-outcome trials to show a diet could rival cardiac drugs.
Why it matters
Mediterranean diet cut cardiac events 72% versus the AHA control diet.
Informs: Heart Disease
Provenance
- Design
- Randomised controlled trial
- Sample size (n)
- 605
- Follow-up
- 4 years
- Peer-reviewed
- Yes
- Replications
- 3
- Funding
- Public / academic
- Funders
- French Ministry of Health, INSERM
- Institutions
- Lyon University Hospital, INSERM
decades.plus score
A transparent 0–100 weighted sum across six components. Higher scores reflect bigger, cleaner, more replicated work.
Landmark 87/100
Caveats
Single-centre trial in France; smaller sample than later RCTs. The 'control' AHA diet has since evolved, so the comparator differs from current standard of care.
