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Landmark 91/100

UK Biobank — Risks of ischaemic heart disease and stroke in meat eaters, fish eaters, and vegetarians

In plain English

Half a million UK adults reported their diet, then were followed for nearly two decades. Vegetarians and vegans had 22% lower risk of ischaemic heart disease than meat-eaters. Vegetarians did, however, show a small increase in haemorrhagic stroke risk — an honest signal that 'plant-based' is not automatic protection if intake of B12, omega-3 and protein is poor.

Why it matters

Vegans had 22% lower CVD risk across 500,000 participants — but a slight uptick in haemorrhagic stroke.

Informs: Heart Disease·Stroke

Provenance

Design
Prospective cohort
Sample size (n)
500,000
Follow-up
18 years
Peer-reviewed
Yes
Replications
2
Funding
Public / academic
Funders
UK Medical Research Council, Wellcome Trust, Cancer Research UK
Institutions
University of Oxford (Nuffield Department of Population Health)

decades.plus score

A transparent 0–100 weighted sum across six components. Higher scores reflect bigger, cleaner, more replicated work.

Landmark 91/100
  • Study design 20/25
  • Sample size 20/20
  • Funding independence 20/20
  • Journal + peer review 15/15
  • Institution tier 10/10
  • Replication 6/10

Caveats

Observational; vegetarians may differ in unmeasured ways (less smoking, more exercise). The stroke signal is small and may reflect under-replacement of B12 / animal nutrients.